Apoptosis induced by Staphylococcus aureus in epithelial cells utilizes a mechanism involving caspases 8 and 3.

@article{Wesson2000ApoptosisIB,
  title={Apoptosis induced by Staphylococcus aureus in epithelial cells utilizes a mechanism involving caspases 8 and 3.},
  author={C A Wesson and J R Deringer and Linda E Liou and Kenneth W Bayles and Gregory A. Bohach and William R. Trumble},
  journal={Infection and immunity},
  year={2000},
  volume={68 5},
  pages={2998-3001}
}
In this study, we demonstrate that the mechanism by which Staphylococcus aureus induces apoptosis in bovine mammary epithelial (MAC-T) cells involves caspases 8 and 3, two key components of a proteolytic cascade leading to apoptosis. In addition, internalized S. aureus induces expression of the inflammatory cytokines tumor necrosis factor alpha and interleukin-1beta by MAC-T cells. These data suggest that the internalization of S. aureus could induce specific cellular responses in vivo that may… CONTINUE READING