Apoptosis-induced alkalinization by the Na+/H+ exchanger isoform 1 is mediated through phosphorylation of amino acids Ser726 and Ser729.

@article{Grenier2008ApoptosisinducedAB,
  title={Apoptosis-induced alkalinization by the Na+/H+ exchanger isoform 1 is mediated through phosphorylation of amino acids Ser726 and Ser729.},
  author={Amy L Grenier and Khaled Abu-ihweij and Ge Zhang and Shannon Moore Ruppert and Rebecca J. Boohaker and Emily R. Slepkov and Kathryn Pridemore and J. Ren and Larry Fliegel and Annette R. Khaled},
  journal={American journal of physiology. Cell physiology},
  year={2008},
  volume={295 4},
  pages={C883-96}
}
Apoptosis is a complex process essential for normal tissue development and cellular homeostasis. While biochemical events that occur late in the apoptotic process are better characterized, early physiological changes that initiate the progression of cell death remain poorly understood. Previously, we observed that lymphocytes, undergoing apoptosis in response to growth factor withdrawal, experienced a rapid and transient rise in cytosolic pH. We found that the protein responsible was the pH… CONTINUE READING
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