Apoptosis in tracheoesophageal embryogenesis in rat embryos with or without adriamycin treatment.

@article{Zhou1999ApoptosisIT,
  title={Apoptosis in tracheoesophageal embryogenesis in rat embryos with or without adriamycin treatment.},
  author={Baiyun Zhou and John M Hutson and Pamela J. Farmer and Suzanne Hasthorpe and Nate A. Myers and Ming-yue Liu},
  journal={Journal of pediatric surgery},
  year={1999},
  volume={34 5},
  pages={872-5; discussion 876}
}
PURPOSE The aim of this study was to determine whether apoptosis participates in separation of the foregut into trachea and esophagus and to evaluate the potential role of apoptosis in the development of esophageal atresia and tracheoesophageal fistula (EA + TEF) induced by Adriamycin. METHODS Timed-pregnant rats were injected daily with either saline or Adriamycin (2 mg/kg) intraperitoneally on days 6 to 9 of gestation. Paraffin sections were prepared from 31 experimental and 31 control… CONTINUE READING

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