Apoptosis in the rat penis after penile denervation.

  title={Apoptosis in the rat penis after penile denervation.},
  author={Lonnie T. Klein and Maureen Miller and Ralph Buttyan and Anthony J Raffo and Michael Burchard and G Devris and Yizhou Cao and Carl Olsson and Ridwan Shabsigh},
  journal={The Journal of urology},
  volume={158 2},
PURPOSE Despite the advances in nerve sparing prostatectomy for prostate cancer, some patients develop impotence or subjectively complain of a decrease in penile size. We hypothesized that these clinical observations may be explained by injury to the cavernous nerves resulting in programmed cell death (apoptosis) within the penis. We utilized a rat model of penile denervation in order to demonstrate apoptosis after denervation. METHODS AND MATERIALS Fifteen male Sprague Dawley rats underwent… CONTINUE READING


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