Apoptosis in the pathogenesis and treatment of disease
@article{Thompson1995ApoptosisIT, title={Apoptosis in the pathogenesis and treatment of disease}, author={Craig B. Thompson}, journal={Science}, year={1995}, volume={267}, pages={1456 - 1462} }
In multicellular organisms, homeostasis is maintained through a balance between cell proliferation and cell death. Although much is known about the control of cell proliferation, less is known about the control of cell death. Physiologic cell death occurs primarily through an evolutionarily conserved form of cell suicide termed apoptosis. The decision of a cell to undergo apoptosis can be influenced by a wide variety of regulatory stimuli. Recent evidence suggests that alterations in cell…
5,113 Citations
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Proper control of programmed cell death is crucial, and breakdown in the regulation of this process can result in a number of pathologies: inactivation of the death program has been associated with the development of cancer and autoimmune diseases, whereas aberrant activation of the apoptotic machinery is thought to contribute to the extensive cell deaths observed in neurodegenerative diseases and stroke.
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The phenomenon of apoptosis, and a number of techniques for its identification and quantification, are reviewed and specific therapies designed to enhance or decrease the susceptibility of individual cell types to undergo apoptosis could form the basis for treatment of diseases.
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Research has begun to elucidate the molecular mechanism underlying the initiation and manifestation of the apoptotic process, and it is now widely accepted that apoptotic cells are killed via a highly ordered and controlled program.
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Understanding the molecular mechanism of apoptosis including death genes, death signals, surface receptors and signal pathways will provide new insights in developing strategies to regulate cell survival/death.
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