Apoptosis in the in Vivo Mammalian Forebrain

@article{Dikranian2001ApoptosisIT,
  title={Apoptosis in the in Vivo Mammalian Forebrain},
  author={Krikor Dikranian and Masahiko J. Ishimaru and Tatyana I. Tenkova and Joann Labruyere and Y Q Qin and Chrysanthy Ikonomidou and John W. Olney},
  journal={Neurobiology of Disease},
  year={2001},
  volume={8},
  pages={359-379}
}
Apoptosis is a word originally introduced by Kerr, Wyllie, and colleagues for a cell death process they defined in terms of its ultrastructural appearance in nonneuronal cells from various tissues. There are very few studies providing detailed ultrastructural criteria for recognizing neuronal apoptosis in the in vivo mammalian brain. In the absence of such criteria, the Kerr/Wyllie description pertaining to nonneuronal cells has served as a reference standard. However, contemporary… Expand
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It is reported that synthetic A beta Ps trigger the degeneration of cultured neurons through activation of an apoptotic pathway, suggesting that apoptosis may play a role in the neuronal loss associated with Alzheimer disease. Expand
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