Apoptosis in the failing human heart.

  title={Apoptosis in the failing human heart.},
  author={Giorgio Olivetti and Revlin Abbi and Federico Quaini and Jan Kajstura and Winston Teng Kuei Cheng and Jim Nitahara and Eugenio L. Quaini and Carla Di Loreto and Carlo Alberto Beltrami and Stanislaw Krajewski and John C. Reed and Piero Anversa},
  journal={The New England journal of medicine},
  volume={336 16},
BACKGROUND Loss of myocytes is an important mechanism in the development of cardiac failure of either ischemic or nonischemic origin. However, whether programmed cell death (apoptosis) is implicated in the terminal stages of heart failure is not known. We therefore studied the magnitude of myocyte apoptosis in patients with intractable congestive heart failure. METHODS Myocardial samples were obtained from the hearts of 36 patients who underwent cardiac transplantation and from the hearts of… CONTINUE READING
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