Apoptosis in procyclic Trypanosoma brucei rhodesiense in vitro.

  title={Apoptosis in procyclic Trypanosoma brucei rhodesiense in vitro.},
  author={Susan Christina Welburn and Charlotte Dale and Danielle Ellis and Robert Beecroft and Terry W. Pearson},
  journal={Cell death and differentiation},
  volume={3 2},
Apoptosis is a phenomenon previously associated exclusively with metazoan organisms. We show here that procyclic insect form Trypanosoma brucei rhodesiense, a protozoan parasite, when treated in vitro with concanavalin A displayed several features normally associated with apoptosis in metazoan cells. Lectin treatment induced cleavage of nuclear DNA into oligonucleosomal fragments, suggesting activation of an endogenous nuclease in the parasite. Treated trypanosomes, although agglutinated and… CONTINUE READING
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