Apoptosis in neuronal development and transplantation: role of caspases and trophic factors.

@article{Boonman1999ApoptosisIN,
  title={Apoptosis in neuronal development and transplantation: role of caspases and trophic factors.},
  author={Z. Boonman and O. Isacson},
  journal={Experimental neurology},
  year={1999},
  volume={156 1},
  pages={1-15}
}
Fetal ventral mesencephalic (VM) transplants have been studied in the context of dopaminergic (DA) replacement therapy for Parkinson's disease (PD). DA neurons from VM transplants will grow axons and form functional synapses in the adult host central nervous system (CNS). Recently, studies have demonstrated that most of the transplanted DA neurons die in grafts within the first week after implantation. An important feature of neural development, also in transplanted developing fetal neural… CONTINUE READING

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