Apoptosis in multiple sclerosis

  title={Apoptosis in multiple sclerosis},
  author={Frauke Zipp},
  journal={Cell and Tissue Research},
Several recent studies have provided evidence that apoptosis is an important feature in the pathogenesis of multiple sclerosis (MS), an autoimmune disease of the central nervous system. Apoptosis presumably plays a role in the immunoregulation via activation-induced T-cell death (AICD) and in local processes of tissue damage. In this review the dual role of apoptosis in the MS pathogenesis and its relevance regarding therapeutic concepts is discussed. 


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Distinct patterns of multiple sclerosis pathology indicate heterogeneity in pathogenesis

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