Apoptosis in keratinocytes is not dependent on induction of differentiation.

  title={Apoptosis in keratinocytes is not dependent on induction of differentiation.},
  author={Raj S. Mitra and T. Wrone-Smith and Philip L. Simonian and Kimberly E. Foreman and Gabriel N{\'u}{\~n}ez and Brian J. Nickoloff},
  journal={Laboratory investigation; a journal of technical methods and pathology},
  volume={76 1},
During embryological development and throughout life, regulation of the thickness of skin is likely to involve modulation of keratinocyte proliferation, differentiation, and cell death. One major mechanism of cell death is apoptosis; but the precise relationship between apoptosis and differentiation has not been well-defined. In this report, we demonstrate that when cultured undifferentiated keratinocytes have their adhesive interactions interrupted by either enzymatic treatment (ie, trypsin… CONTINUE READING