Apoptosis in human monocyte-macrophages exposed to oxidized low density lipoprotein.

  title={Apoptosis in human monocyte-macrophages exposed to oxidized low density lipoprotein.},
  author={Simon J. Hardwick and Laszlo Hegyi and Ken Clare and Nathaniel Law and Keri Carpenter and Malcolm J Mitchinson and Jeremy N. Skepper},
  journal={The Journal of pathology},
  volume={179 3},
This study has demonstrated the toxicity to human monocyte-macrophages of low-density lipoprotein (LDL) which had been artificially oxidized using copper sulphate. The assays of cell damage used were tritiated adenine release, neutral red staining, lactate dehydrogenase leakage, and MTT dye reduction. Toxicity was concentration- and time-dependent. Exposure to native LDL under the same conditions did not result in toxicity. Transmission electron microscopy of cells exposed to oxidized LDL… CONTINUE READING


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