Apoptosis in cardiac transplant rejection.

  title={Apoptosis in cardiac transplant rejection.},
  author={Leslie W. Miller and David James Granville and Jagat S. Narula and Bruce McManus},
  journal={Cardiology clinics},
  volume={19 1},
Apoptosis occurs in human cardiac allograft rejection and may occur with all degrees of rejection and even in its absence. The prevalence and severity of apoptosis is determined predominantly by the intensity of macrophage infiltration and may be mediated by NO-related mechanisms. Apoptosis of interstitial, endothelial, and inflammatory cells is also present in heart allografts and may influence the degree and extent of vascular injury contributing to allograft rejection. Ongoing apoptosis of… CONTINUE READING

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