Apoptosis in cardiac diseases: stress- and mitogen-activated signaling pathways.

  title={Apoptosis in cardiac diseases: stress- and mitogen-activated signaling pathways.},
  author={Giora G Z Feuerstein and Peter R. Young},
  journal={Cardiovascular research},
  volume={45 3},
Apoptosis is a form of cell death that involves discrete genetic and molecular programs, de novo protein expression and a unique cellular phenotype. Evidence for the existence of apoptosis in the human heart has been reported in various cardiac diseases, including ischemic and non-ischemic heart failure, myocardial infarction and arrhythmias. Among the most potent stimuli that elicit cardiomyocyte apoptosis are: oxygen radicals (including NO), cytokines (FAS/TNF alpha-receptor signaling… CONTINUE READING
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