Apoptosis in atherosclerosis: focus on oxidized lipids and inflammation.

  title={Apoptosis in atherosclerosis: focus on oxidized lipids and inflammation.},
  author={Wim Martinet and Mark M. Kockx},
  journal={Current opinion in lipidology},
  volume={12 5},
An increasing body of evidence from both animal models and human specimens suggests that apoptosis or programmed cell death is a major event in the pathophysiology of atherosclerosis. Although the significance of apoptosis in atherosclerosis remains unclear, it has been proposed that apoptotic cell death contributes to plaque instability, rupture and thrombus formation. Biochemical and genetic analyses of apoptosis provide an increasingly detailed picture of the intracellular signaling pathways… CONTINUE READING

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