Apoptosis in Xenopus tadpole tail muscles involves Bax-dependent pathways.

  title={Apoptosis in Xenopus tadpole tail muscles involves Bax-dependent pathways.},
  author={Laurent M. Sachs and B Abdallah and Anjum Hassan and Giovanni Levi and Amaury de Luze and John C. Reed and Barbara A Demeneix},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  volume={11 10},
Apoptosis is a fundamental mechanism implicated in normal development. One of the most spectacular developmental events involving apoptosis is tail regression during amphibian metamorphosis. We analyzed how thyroid hormone (3, 5, 3'-triiodothyronine, T3), the orchestrator of metamorphosis, affects expression and function of the proapoptotic gene Bax in the tail muscle of free-living Xenopus tadpoles. During natural metamorphosis Bax mRNA was expressed in tail muscles and was spatially… CONTINUE READING

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