Apoptosis in Parkinson's disease: signals for neuronal degradation.

  title={Apoptosis in Parkinson's disease: signals for neuronal degradation.},
  author={William G. Tatton and R M E Chalmers-Redman and David Benjamin Brown and Nadine A Tatton},
  journal={Annals of neurology},
  volume={53 Suppl 3},
  pages={S61-70; discussion S70-2}
Controversy has surrounded a role for apoptosis in the loss of neurons in Parkinson's disease (PD). Although a variety of evidence has supported an apoptotic contribution to PD neuronal loss particularly in the nigra, two factors have weighed against general acceptance: (1) limitations in the use of in situ 3' end labeling techniques to demonstrate nuclear DNA cleavage; and (2) the insistence that a specific set of nuclear morphological features be present before apoptotic death could be… CONTINUE READING


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