Apoptosis facilitates antigen presentation to T lymphocytes through MHC-I and CD1 in tuberculosis

@article{Schaible2003ApoptosisFA,
  title={Apoptosis facilitates antigen presentation to T lymphocytes through MHC-I and CD1 in tuberculosis},
  author={Ulrich Emil Schaible and Florian Winau and Peter Allan Sieling and Karsten Fischer and Helen L. Collins and Kristine Hagens and Robert L Modlin and V Brinkmann and Stefan H. E. Kaufmann},
  journal={Nature Medicine},
  year={2003},
  volume={9},
  pages={1039-1046}
}
Protective immunity against Mycobacterium tuberculosis involves major histocompatibility complex class I (MHC-I)- and CD1-restricted CD8 T cells, but the mechanisms underlying antigen delivery to antigen-presenting molecules remain enigmatic. Macrophages, the primary host cells for mycobacteria, are CD1-negative. Here we show that M. tuberculosis phagosomes are secluded from the cytosolic MHC-I processing pathway and that mycobacteria-infected cells lose their antigen-presenting capacity. We… CONTINUE READING
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Antimicrobial activity of MHC class I - restricted CD 8 + T cells in human tuberculosis

  • S. Cho
  • Proc . Natl . Acad . Sci . USA
  • 2000

CD 1 c - mediated T - cell recognition of isoprenoid glycolipids in Mycobacterium tuberculosis infection

  • D. B. Moody
  • Nature
  • 2000

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