Apoptosis enzyme-linked immunosorbent assay distinguishes anticancer drugs from toxic chemicals and predicts drug synergism.

@article{Frankfurt2003ApoptosisEI,
  title={Apoptosis enzyme-linked immunosorbent assay distinguishes anticancer drugs from toxic chemicals and predicts drug synergism.},
  author={O. Frankfurt and A. Krishan},
  journal={Chemico-biological interactions},
  year={2003},
  volume={145 1},
  pages={
          89-99
        }
}
  • O. Frankfurt, A. Krishan
  • Published 2003
  • Chemistry, Medicine
  • Chemico-biological interactions
  • The effects of anticancer drugs and toxic compounds on leukemic cells in culture were evaluated by enzyme-linked-immunosorbent assay (ELISA) based on the detection of apoptotic cells by a monoclonal antibody against single-stranded DNA. The concentrations of 13 anticancer drugs, which increased apoptosis ELISA absorbance, were similar to the concentrations decreasing long-term cell survival. Short-term metabolic tetrazolium-based 3-(4,5-dimethylthiazol-yl)-2,5-diphenyformazan bromide (MTT… CONTINUE READING
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