Apoptosis enhanced by soluble factor produced in feline immunodeficiency virus infection.

@article{Mizuno1997ApoptosisEB,
  title={Apoptosis enhanced by soluble factor produced in feline immunodeficiency virus infection.},
  author={Takeshi Mizuno and Yasuyuki Momoi and Yasuyuki Endo and Yorihiro Nishimura and Yuko Goto and Koichi Ohno and Toshihiro Watari and Hajime Tsujimoto and Atsuhiko Hasegawa},
  journal={The Journal of veterinary medical science},
  year={1997},
  volume={59 11},
  pages={1049-51}
}
Feline immunodeficiency virus (FIV)-infected cells have been shown to undergo apoptosis by treatment with tumor necrosis factor alpha (TNF-alpha). This study detected a soluble factor which enhanced the apoptosis induced by TNF-alpha treatment. The sensitivity to TNF-alpha in the induction of apoptosis in a feline fibroblastoid cell line (CRFK) cells was significantly enhanced when the culture supernatant of FIV-infected CRFK cells or plasma samples from FIV-infected cats was added to the… CONTINUE READING