Apoptosis during bone-like tissue development in vitro.

  title={Apoptosis during bone-like tissue development in vitro.},
  author={Maureen P Lynch and Casey Capparelli and Janet L Stein and Gary S Stein and Jane B Lian},
  journal={Journal of cellular biochemistry},
  volume={68 1},
We present evidence of cell death by apoptosis during the development of bone-like tissue formation in vitro. Fetal rat calvaria-derived osteoblasts differentiate in vitro, progressing through three stages of maturation: a proliferation period, a matrix maturation period when growth is downregulated and expression of the bone cell phenotype is induced, and a third mineralization stage marked by the expression of bone-specific genes. Here we show for the first time that cells differentiating to… CONTINUE READING