Apoptosis defects and chemotherapy resistance: molecular interaction maps and networks

@article{Pommier2004ApoptosisDA,
  title={Apoptosis defects and chemotherapy resistance: molecular interaction maps and networks},
  author={Yves Pommier and Olivier Sordet and Smitha Antony and Richard Laurence Hayward and Kurt W. Kohn},
  journal={Oncogene},
  year={2004},
  volume={23},
  pages={2934-2949}
}
Intrinsic (innate) and acquired (adaptive) resistance to chemotherapy critically limits the outcome of cancer treatments. For many years, it was assumed that the interaction of a drug with its molecular target would yield a lethal lesion, and that determinants of intrinsic drug resistance should therefore be sought either at the target level (quantitative changes or/and mutations) or upstream of this interaction, in drug metabolism or drug transport mechanisms. It is now apparent that… CONTINUE READING

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