Apoptosis by Death Factor

@article{Nagata1997ApoptosisBD,
  title={Apoptosis by Death Factor},
  author={Shigekazu Nagata},
  journal={Cell},
  year={1997},
  volume={88},
  pages={355-365}
}
  • S. Nagata
  • Published 7 February 1997
  • Biology, Medicine
  • Cell
I thank Drs. D. V. Goeddel and P. Golstein for helpful comments on the manuscript. I am grateful to all members of my laboratory in Osaka University Medical School and Osaka Bioscience Institute, and to Dr. O. Hayaishi for encouragement and discussion. I thank Drs. L. Migletta and G. Gray of Clarify Editing for careful editing of the manuscript. The work in my laboratory was supported in part by Grants-in-Aid from the Ministry of Education, Science, and Culture of Japan and by a Research Grant… Expand
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Because of the limited number of references allowed, the authors were unable to cite many important papers; they apologize to their authors. Expand
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Although protection of cells against apoptotic death can be influenced by the level of expression of BCl-2 and Bcl-xL, post-translational modification of B cl-2 family members appears to be important as well. Expand
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It is reported here that Fas/APO-1-mediated apoptosis requires the activation of a new class of cysteine proteases, including interleukin-lβ-converting enzyme (ICE)8á[euro]-10, which are homologous to the product of the Caenorhabditis elegans cell-death gene ced-3 (refs 11, 12). Expand
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