Apoptosis-associated generation of reactive oxygen intermediates and release of pro-inflammatory cytokines in human lymphocytes and granulocytes by extracts from the seeds of Acalypha wilkesiana.

@article{Bssing1999ApoptosisassociatedGO,
  title={Apoptosis-associated generation of reactive oxygen intermediates and release of pro-inflammatory cytokines in human lymphocytes and granulocytes by extracts from the seeds of Acalypha wilkesiana.},
  author={Arndt B{\"u}ssing and Gerburg Maria Stein and I Herterich-Akinpelu and Uwe Pf{\"u}ller},
  journal={Journal of ethnopharmacology},
  year={1999},
  volume={66 3},
  pages={301-9}
}
Seeds from Acalypha wilkesiana (Euphorbiaceae) are an essential component of a complex plant mixture used empirically by traditional healers in Southwest Nigeria to treat breast tumours and inflammation. To investigate their biological properties, we incubated human lymphocytes and granulocytes with aqueous and ethanolic extracts of A. wilkesiana seeds (AWS). In lymphocytes, we observed an induction of apoptosis and generation of reactive oxygen intermediates (ROI), as measured by the oxidation… CONTINUE READING

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