Apoptosis as a therapeutic paradigm in inflammatory bowel diseases.

  title={Apoptosis as a therapeutic paradigm in inflammatory bowel diseases.},
  author={Marleen I. Verstege and Anje A. te Velde and Daniel W. Hommes},
  journal={Acta gastro-enterologica Belgica},
  volume={69 4},
Evidence is increasing that a defect in apoptosis is involved in the pathogenesis of inflammatory bowel diseases (IBD), including Crohn's disease (CD) and ulcerative colitis (UC). CD seems to be the cause of an intrinsic defect in the apoptotic pathway of (autoreactive) T cells, resulting in excessive T cell responses. In UC, an increased rate of apoptosis of epithelial cells is observed. In this review we will describe apoptotic mechanisms and their association to IBD. In addition, we will… CONTINUE READING

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