Apoptosis and tumorigenesis in human cholangiocarcinoma cells. Involvement of Fas/APO-1 (CD95) and calmodulin.

Abstract

We have previously demonstrated that tamoxifen inhibits the growth of human cholangiocarcinoma cells in culture and inhibits tumor growth when cells are injected into nude mice. However, the mechanism of action of tamoxifen remains unknown. Here we demonstrate that tamoxifen and trifluoperazine, both potent calmodulin antagonists, induce apoptosis in vitro… (More)

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@article{Pan1999ApoptosisAT, title={Apoptosis and tumorigenesis in human cholangiocarcinoma cells. Involvement of Fas/APO-1 (CD95) and calmodulin.}, author={G Z Pan and Selwyn Maurice Vickers and Allan Pickens and Jack O. Phillips and W. Ying and John A. Thompson and G P Siegal and J. Matthew McDonald}, journal={The American journal of pathology}, year={1999}, volume={155 1}, pages={193-203} }