Apoptosis and the liver: relation to autoimmunity and related conditions.

  title={Apoptosis and the liver: relation to autoimmunity and related conditions.},
  author={Jingxiang Bai and Joseph A. Odin},
  journal={Autoimmunity reviews},
  volume={2 1},
Apoptosis is a normal physiologic form of cell death that follows activation of either an intrinsic or extrinsic pathway. In the intrinsic, various stimuli, such as oxidative stress, lead to mitochondrial dysfunction and the release of pro-apoptotic factors. Ligand binding to cell surface death receptors, such as Fas, activates the extrinsic pathway. Due to the rapid clearance of apoptotic cells, detection and quantification of apoptotic cells is prone to underestimation. In the liver, the… CONTINUE READING
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