Apoptosis and reduced influenza A virus specific CD8+ T cells in aging mice

@article{Zhang2002ApoptosisAR,
  title={Apoptosis and reduced influenza A virus specific CD8+ T cells in aging mice},
  author={Yanhong Zhang and Yun Wang and Xyanthine Gilmore and Ken Xu and M Chen and P Tebebi and Innocent Nnadi Mbawuike},
  journal={Cell Death and Differentiation},
  year={2002},
  volume={9},
  pages={651-660}
}
Some studies have reported increased apoptosis in CD8+ T cells from aged mice. We previously demonstrated diminished virus-specific CD8+ cytotoxic T lymphocyte (CTL) activity in aged mice in comparison to young mice. The present study investigated the role of apoptosis in age-related influenza virus-specific CD8+ CTL deficiency. Splenocytes from influenza-primed aged and young mice were stimulated in vitro with virus. The CD8+ T cell/total lymphocyte ratios correlated with CTL activity and were… CONTINUE READING