Apoptosis and proliferation of dentate gyrus neurons after single and intermittent limbic seizures.

@article{Bengzon1997ApoptosisAP,
  title={Apoptosis and proliferation of dentate gyrus neurons after single and intermittent limbic seizures.},
  author={J. Bengzon and Z. Kokaia and E. Elm{\'e}r and A. Nanobashvili and M. Kokaia and O. Lindvall},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1997},
  volume={94 19},
  pages={
          10432-7
        }
}
  • J. Bengzon, Z. Kokaia, +3 authors O. Lindvall
  • Published 1997
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
Neuronal apoptosis was observed in the rat dentate gyrus in two experimental models of human limbic epilepsy. Five hours after one hippocampal kindling stimulation, a marked increase of in situ terminal deoxynucleotidyltransferase-mediated dUTP nick-end labeling (TUNEL) of fragmented DNA was observed in nuclei located within and on the hilar border of the granule cell layer and in the polymorphic region. Forty kindling stimulations with 5-min interval produced higher numbers of labeled nuclei… Expand
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