Apoptosis and programmed cell death in immunity.

  title={Apoptosis and programmed cell death in immunity.},
  author={J. John Cohen and Richard C. Duke and Valerie Fadok and Karen S. Sellins},
  journal={Annual review of immunology},
Death of some cells in the mammalian body is clearly programmed. In the immune system there are many examples of programmed cell death, during development of lymphocytes as well as at later stages, after interaction with antigen. Many of these examples display the morphology of apoptosis: They undergo shrinkage and zeiosis, the nucleus collapses, and chromatin is cleaved into nucleosomal fragments. The cell is rapidly recognized by phagocytes and disposed of without releasing its contents. In… CONTINUE READING

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