Apoptosis and nitrative stress associated with phosphodiesterase inhibitor-induced mesenteric vasculitis in rats.

@article{Slim2003ApoptosisAN,
  title={Apoptosis and nitrative stress associated with phosphodiesterase inhibitor-induced mesenteric vasculitis in rats.},
  author={Rabih M Slim and Yunling Song and Mudher Albassam and Lloyd A. Dethloff},
  journal={Toxicologic pathology},
  year={2003},
  volume={31 6},
  pages={638-45}
}
Nitric oxide may play a role in phosphodiesterase (PDE) inhibitor-induced rat mesenteric vasculitis. The present study was conducted to identify cellular sources of iNOS, determine the distribution of nitrotyrosine (NT) residues as a footprint of peroxynitrite (ONOO-) production, and evaluate their association with vascular apoptosis. To dissociate primary events from secondary changes associated with the inflammatory response, rats were given the PDE IV inhibitor CI-1018 orally at 750 mg/kg… CONTINUE READING

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An increased regional blood flow precedes mesenteric inflammation in rats treated by a phosphodiesterase 4 inhibitor.

Toxicological sciences : an official journal of the Society of Toxicology • 2009
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