Corpus ID: 41835132

Apoptosis and necrosis. Basic types and mechanisms of cell death.

@article{Buja1993ApoptosisAN,
  title={Apoptosis and necrosis. Basic types and mechanisms of cell death.},
  author={Louis Maximilian Buja and Marsha L. Eigenbrodt and Edwin H. Eigenbrodt},
  journal={Archives of pathology \& laboratory medicine},
  year={1993},
  volume={117 12},
  pages={
          1208-14
        }
}
Apoptosis and necrosis are two fundamental types of cell death. Current knowledge indicates that the key mechanism of apoptosis is endonuclease activation leading to internucleosomal double-stranded chromatin (DNA) breaks, whereas the key mechanism of necrosis is cell membrane damage. The initial alterations of cellular metabolism and electrolyte homeostasis induced by an injurious agent may activate at least four major pathways leading to loss of membrane integrity: membrane phospholipid… Expand
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