Apoptosis and necrosis in cerebrovascular disease.

  title={Apoptosis and necrosis in cerebrovascular disease.},
  author={Barbara Joy Snider and Frank J Gottron and Dennis W. Choi},
  journal={Annals of the New York Academy of Sciences},
Neuronal death following ischemic insults has been thought to reflect necrosis. However, recent evidence from several labs suggests that programmed cell death, leading to apoptosis, might additionally contribute to this death. We have used both in vitro and in vivo models to study the role of apoptosis in ischemic cell death. Some features of apoptosis (TUNEL staining, internucleosomal DNA fragmentation, sensitivity to cycloheximide) were observed following transient focal ischemia in rats… CONTINUE READING


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