Apoptosis and insulin resistance in liver and peripheral tissues of morbidly obese patients is associated with different stages of non-alcoholic fatty liver disease

@article{Ferreira2011ApoptosisAI,
  title={Apoptosis and insulin resistance in liver and peripheral tissues of morbidly obese patients is associated with different stages of non-alcoholic fatty liver disease},
  author={Duarte M. S. Ferreira and Rui Sarmento e Castro and Mariana Verdelho Machado and Teresinha Evangelista and Antonio Silvestre and Ad{\'i}lia Costa and Jo{\~a}o Ara{\'u}jo Pereira Coutinho and Fatima M. Carepa and Helena Cortez-Pinto and Cec{\'i}lia Maria Pereira Rodrigues},
  journal={Diabetologia},
  year={2011},
  volume={54},
  pages={1788-1798}
}
Non-alcoholic fatty liver disease (NAFLD) is associated with insulin resistance and characterised by different degrees of hepatic lesion. Its pathogenesis and correlation with apoptosis and insulin resistance in insulin target tissues remains incompletely understood. We investigated how insulin signalling, caspase activation and apoptosis correlate with different NAFLD stages in liver, muscle and visceral adipose tissues. Liver, muscle and adipose tissue biopsies from 26 morbidly obese patients… CONTINUE READING
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