Apoptosis and human diseases: mitochondrion damage and lethal role of released cytochrome C as proapoptotic protein.

@article{Caroppi2009ApoptosisAH,
  title={Apoptosis and human diseases: mitochondrion damage and lethal role of released cytochrome C as proapoptotic protein.},
  author={Paola Caroppi and Federica Sinibaldi and Laura Fiorucci and Roberto Santucci},
  journal={Current medicinal chemistry},
  year={2009},
  volume={16 31},
  pages={
          4058-65
        }
}
Apoptosis is strictly connected to the pathogenesis of many human diseases, including neoplastic, neurodegenerative or cardiovascular diseases. It is a highly programmed cell death which can be activated by various factors. Mitochondria play a key role in the apoptotic process; their damage, which involves permeabilization of the outer mitochondrial membrane, activates a series of events that lead to cell death. Of the two proposed signaling pathways of apoptosis, i.e. the 'extrinsic' and the… CONTINUE READING

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