Apoptosis and host restriction of vaccinia virus in RK13 cells.

@article{Chung1997ApoptosisAH,
  title={Apoptosis and host restriction of vaccinia virus in RK13 cells.},
  author={C S Chung and Irina A. Vasilevskaya and S. C. Wang and C. H. Bair and Wen Chang},
  journal={Virus research},
  year={1997},
  volume={52 2},
  pages={
          121-32
        }
}
  • C S Chung, Irina A. Vasilevskaya, +2 authors Wen Chang
  • Published in Virus research 1997
  • Biology, Medicine
  • Poxviruses express a number of host range (hr) genes that control virus growth in distinctive cell types. Inactivation of hr gene expression in several reported cases has led to apoptosis of virus-infected cells. In RK13 cells, the K1L gene serves as a hr gene for vaccinia virus. We therefore investigated the effect of K1L expression in apoptosis of RK13 cells. In contrast to other hr genes, no significant increase of apoptosis was detected in RK13 cells infected with a K1L- mutant virus. Also… CONTINUE READING

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