Apoptosis and cancer stem cells: Implications for apoptosis targeted therapy.

  title={Apoptosis and cancer stem cells: Implications for apoptosis targeted therapy.},
  author={Frank A. E. Kruyt and Jan Jacob Schuringa},
  journal={Biochemical pharmacology},
  volume={80 4},
Evidence is accumulating showing that cancer stem cells or tumor-initiating cells are key drivers of tumor formation and progression. Successful therapy must therefore eliminate these cells, which is hampered by their high resistance to commonly used treatment modalities. Thus far, only a limited number of studies have addressed the cancer stem cell killing potential of apoptosis targeted therapies and mechanisms of apoptosis resistance in these cells. Apoptosis resistance may involve inherent… CONTINUE READING

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