Apoptosis and cancer chemotherapy

@article{Makin2000ApoptosisAC,
  title={Apoptosis and cancer chemotherapy},
  author={Guy W.J. Makin and John A. Hickman},
  journal={Cell and Tissue Research},
  year={2000},
  volume={301},
  pages={143-152}
}
Abstract Apoptosis is a fundamental mechanism of cell death that can be engaged by a range of cellular insults. One of the major modes of action of chemotherapeutic drugs may be via the activation of apoptosis. Understanding how the cell death program is engaged following an insult, and hence why it fails to be engaged in certain settings, offers a novel approach to overcoming the clinical problem of drug resistance. The tumour suppressor gene p53 and its downstream effector genes p21, mdm-2… 

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