Apoptosis and cancer: mutations within caspase genes.


The inactivation of programmed cell death has profound effects not only on the development but also on the overall integrity of multicellular organisms. Beside developmental abnormalities, it may lead to tumorigenesis, autoimmunity, and other serious health problems. Deregulated apoptosis may also be the leading cause of cancer therapy chemoresistance… (More)
DOI: 10.1136/jmg.2009.066944


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