Apoptosis and cancer: insights molecular mechanisms and treatments

@inproceedings{Zahid2015ApoptosisAC,
  title={Apoptosis and cancer: insights molecular mechanisms and treatments},
  author={Iqbal Zahid and Ataur Rahman and Tipu Sultan and Rokibul Islam},
  year={2015}
}
Apoptosis is a form of cell death that permits the removal of damaged, senescent or unwanted cells in multicellular organisms, without damage to the cellular microenvironment, but it is also involved in a wide range of pathological processes, including cancer. An understanding of the underlying mechanism of apoptosis is important as it plays a pivotal role in the pathogenesis of many diseases. Defective apoptosis represents a major causative factor in the development and progression of cancer… 
Methyl Jasmonate: Putative Mechanisms of Action on Cancer Cells Cycle, Metabolism, and Apoptosis
TLDR
The complete lack of toxicity to normal cells and the rapidity by which MJ causes damage to cancer cells turn MJ into a promising anticancer agent that can be used alone or in combination with other agents.
Voltage-Dependent Anion Channel 1 As an Emerging Drug Target for Novel Anti-Cancer Therapeutics
TLDR
This review presents an overview on the multi-functional mitochondrial protein VDAC1 performing several functions and interacting with distinct sets of partners to regulate both cell life and death, and highlights the importance of the protein for cancer cell survival.
Cordycepin induces autophagy-mediated c-FLIPL degradation and leads to apoptosis in human non-small cell lung cancer cells
TLDR
It is shown that cordycepin induces apoptosis through autophagy-mediated downregulation of c-FLIPL in human NSCLC cells, providing a novel prospect on the anti-tumor property of Cordyceps militaris.
Zerumbone-loaded nanostructured lipid carrier induces G2/M cell cycle arrest and apoptosis via mitochondrial pathway in a human lymphoblastic leukemia cell line
TLDR
Findings show that the Zerumbone (ZER)-loaded nanostructured lipid carrier (NLC) prepared by hot high-pressure homogenization techniques in an acute human lymphoblastic leukemia (Jurkat) cell line in vitro is a potentially useful treatment for acute lymphoblasts in humans.
Manilkara zapota (L.) P. Royen Leaf Water Extract Induces Apoptosis in Human Hepatocellular Carcinoma (HepG2) Cells via ERK1/2/Akt1/JNK1 Signaling Pathways
TLDR
Overall analyses revealed that Manilkara zapota leaf water extract can increase percentage of early apoptotic cells, induce the formation of ROS, upregulate c-Jun N-terminal kinase 1 (JNK1) and inducible nitric oxide synthase (iNOS), and reduce Akt1 and vascular endothelial growth factor A (VEGFA) transcriptional activities.
Unique expression of the xbp1 gene correlates with human prostate cancer
TLDR
Induction of UPR triggers an adaptive pathway to ultimately regain ER homeostasis mediated by three UPR sensors, which become activated and induce the downstream targets under ER stress conditions.
Anti-tumor effects of (1→3)-β-d-glucan from Saccharomyces cerevisiae in S180 tumor-bearing mice.
Cancer and Chemoprevention: An Overview
...
...

References

SHOWING 1-10 OF 86 REFERENCES
Targeting Apoptosis Pathways in Cancer Therapy
TLDR
The current understanding of the apoptotic pathways, including the extrinsic (cytoplasmic) and intrinsic (mitochondrial) pathways, and the agents being developed to target these pathways are reviewed.
Caspases and cancer: mechanisms of inactivation and new treatment modalities.
TLDR
The various defects in caspase-dependent cell death machinery identified in the neoplastic cells are summarized, including not only mutations, but also alterations of gene methylation, and altered mRNA stability.
The Inhibitor of Apoptosis Proteins as Therapeutic Targets in Cancer
TLDR
The role of I AP proteins in cancer and options for targeting IAP proteins for therapeutic intervention are discussed.
Inhibitor of apoptosis proteins and apoptosis.
TLDR
The classification, molecular structures, and properties of IAPs are described and the mechanisms of apoptosis are discussed and the promising significance of clinical applications of I APs in the diagnosis and treatment of malignancy is discussed.
Bcl-2 family proteins: regulators of apoptosis and chemoresistance in hematologic malignancies.
TLDR
Information about the biochemical mechanisms of action of the Bcl-2 protein and other members of the bCL-2 family is beginning to suggest strategies for overcoming the cytoprotective effects of B cl-2 overexpression in lymphomas, leukemias, and other types of cancer.
Overcoming cancer therapy resistance by targeting inhibitors of apoptosis proteins and nuclear factor-kappa B.
TLDR
In other cancer cells that are resistant to TNFalpha or chemo/radiotherapy, Smac-mimetic IAP-inhibitors can enhance ionizing radiation or tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis, indicating the potential role of Smac -mimetics in overcoming acquired therapy-resistance.
Survivin as a target for new anticancer interventions
TLDR
Preclinical studies have demonstrated that down‐regulation of survivin expression/function increased the apoptotic rate, reduced tumor‐growth potential and sensitized tumor cells to chemotherapeutic drugs with different action mechanisms and γ‐irradiation in in vitro and in vivo models of different human tumor types.
Bcl-2 family-regulated apoptosis in health and disease
TLDR
How excessive or insuf- ficient cell death can contribute to disease, and how targeting the Bcl-2 family offers novel therapeutic opportunities are discussed.
Targeting survivin in cancer therapy: fulfilled promises and open questions.
TLDR
Preclinical studies have demonstrated that down-regulation of survivin expression or function, accomplished by means of various strategies, reduced tumor growth potential, increased the apoptotic rate and sensitized tumor cells to chemotherapeutic drugs and radiation in different human tumor models.
Morphologic and biochemical hallmarks of apoptosis.
...
...