Apoptosis and DNA degradation induced by 1-methyl-4-phenylpyridinium in neurons.

@article{Dipasquale1991ApoptosisAD,
  title={Apoptosis and DNA degradation induced by 1-methyl-4-phenylpyridinium in neurons.},
  author={Bruno Dipasquale and Ann M. Marini and Richard J Youle},
  journal={Biochemical and biophysical research communications},
  year={1991},
  volume={181 3},
  pages={1442-8}
}
Apoptosis is a prominent mechanism of programmed cell death in lymphocytes and in cancer cells not previously found in neurons. We have identified apoptosis and internucleosomal DNA degradation in cultures of cerebellar granule neurons. 1-methyl-4-phenylpyridinium, a selective neurotoxin that destroys the dopaminergic nigrostriatal pathway and results in a parkinsonian syndrome, increases the rate of apoptosis and kills cerebellar granule cells in culture via induction of programmed cell death… CONTINUE READING