Apoptosis and Caspase 3 Pathway Role on Anti-Proliferative Effects of Scrophulariaoxy Sepala Methanolic Extract on Caco-2 Cells.

  title={Apoptosis and Caspase 3 Pathway Role on Anti-Proliferative Effects of Scrophulariaoxy Sepala Methanolic Extract on Caco-2 Cells.},
  author={Ali Namvaran and Mehdi Fazeli and Safar Farajnia and Gholamreza Hamidian and Hassan Rezazadeh},
  journal={Drug research},
  volume={67 9},
Colorectal cancer is one the most important malignancies worldwide and finding new treatment option for this cancer is of high priority. Natural compounds are common source of drugs for treatment of various diseases including cancers. The aim of this study was to investigate the effects of Scrophularia oxysepala extract on Caco-2 cells and explore the possible role of caspase 3 pathway in inducing cell death in this cancer cells in compare with chemotherapy agents of cisplatin and capecitabine… 
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The Cytotoxic Effects of Hydroalcoholic Extract of Aerial Parts of Scrophularia striata on MCF-7 Cell Line and Evaluation of BAX and KAI1 Genes Expression
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Dichloromethane fractions of Scrophularia oxysepala extract induce apoptosis in MCF-7 human breast cancer cells.
Fraction of Scrophularia oxysepala extract were found to be promising in growth inhibition and induction of apoptosis in MCF-7 breast cancer cells.
Dichloromethane and Methanol Extracts of Scrophularia oxysepala Induces Apoptosis in MCF-7 Human Breast Cancer Cells.
The studies suggest that this plant may contain potential bioactive compound(s) for the treatment of breast cancer.
Cytotoxic and Apoptotic Activities of Methanolic Subfractions of Scrophularia oxysepala against Human Breast Cancer Cell Line
Scrophularia oxysepala methanolic subfractions induce apoptosis in MCF-7 and WEHI-164 cells and could be considered as a source of natural anticancer agents.
Effects of Scrophularia ningpoensis Hemsl. on Inhibition of Proliferation, Apoptosis Induction and NF-κB Signaling of Immortalized and Cancer Cell Lines
Microarray-based bioinformatical analyses on the compound acetoside from Scrophularia revealed a gene expression profile which confirmed the findings with the extract on proliferation inhibition, anti-inflammation and apoptosis, with DNA alkylation as major proposed mechanism of action.
Scrophularia orientalis extract induces calcium signaling and apoptosis in neuroblastoma cells
Analysis of the anticancer effects of a dichloromethane extract from Scrophularia orientalis revealed that cell death induced by this extract was associated with intracellular calcium release, opening of the MPTP, caspase 3- and PARP-cleavage suggesting that this extract induced aberrant calcium signaling that resulted in apoptosis via the mitochondrial pathway.
Gardenin B-induced cell death in human leukemia cells involves multiple caspases but is independent of the generation of reactive oxygen species.
Investigation of the antiproliferative activity of the flavonoids isolated from Baccharis scandens against human leukemia cell lines found that the methoxyflavonoid gardenin B was the most cytotoxic compound against HL-60 and U-937 cells, but had no significant cytot toxic effects against quiescent or proliferating human peripheral blood mononuclear cells.
Effects of Scrophularia extracts on tumor cell proliferation, death and intravasation through lymphoendothelial cell barriers.
Methanol extracts of Scrophularia species exhibited strong anti-proliferative properties and this was most likely due to the down-regulation of various cell cycle regulators, proto-oncogenes and cell, and NF-κB and the activation of caspase-3.
Differential Effect of Grape Seed Extract against Human Non-small-Cell Lung Cancer Cells: The Role of Reactive Oxygen Species and Apoptosis Induction
GSE treatment caused a strong superoxide radical-associated oxidative stress, significantly decreased intracellular reduced glutathione levels, suggesting, for the first time, the involvement of GSE-caused oxidative stress in its apoptotic inducing activity in these cells.
Cytotoxic activity of Thai medicinal plants against human cholangiocarcinoma, laryngeal and hepatocarcinoma cells in vitro
The ethanolic extracts from five plants and one folklore recipe showed potent cytotoxic activity against CL-6 cell, and HepG2 appears to be the most resistant to the tested extracts.
Transmission of apoptosis in human colorectal tumor cells exposed to capecitabine, Xeloda, is mediated via Fas.
Data show that TP plays a key role in the capecitabine activity and that the Fas/FasL system could be considered as a new determinant for Xeloda efficacy.