Apoptosis Sensitization by Euphorbia Factor L1 in ABCB1-Mediated Multidrug Resistant K562/ADR Cells

@inproceedings{Zhang2013ApoptosisSB,
  title={Apoptosis Sensitization by Euphorbia Factor L1 in ABCB1-Mediated Multidrug Resistant K562/ADR Cells},
  author={Jian-Ye Zhang and Min-ting Lin and Tao Yi and Yina Tang and Lanlan Fan and Xi-cheng He and Zhong-zhen Zhao and Hu-Biao Chen},
  booktitle={Molecules},
  year={2013}
}
In this article, reversal activities of Euphorbia factor L1 (EFL1) against ABCB1-mediated multidrug resistance (MDR) and apoptosis sensitization in K562/ADR cells are reported. EFL1 decreased the IC50 values of anticancer agents in K562/ADR cells over-expressing ABCB1. However, EFL1 did not affect the IC50 values of anticancer agents in sensitive K562 cells. Additionally, EFL1 increased the intracellular accumulation of rhodamine 123 and doxorubicin in K562/ADR cells without affecting their… CONTINUE READING

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