Apoptosis Is Essential for Neutrophil Functional Shutdown and Determines Tissue Damage in Experimental Pneumococcal Meningitis

@article{Koedel2009ApoptosisIE,
  title={Apoptosis Is Essential for Neutrophil Functional Shutdown and Determines Tissue Damage in Experimental Pneumococcal Meningitis},
  author={Uwe Koedel and Tobias Frankenberg and Susanne Kirschnek and Bianca Obermaier and Hans H{\"a}cker and Robert Paul and Georg H{\"a}cker},
  journal={PLoS Pathogens},
  year={2009},
  volume={5},
  pages={1191 - 1197}
}
During acute bacterial infections such as meningitis, neutrophils enter the tissue where they combat the infection before they undergo apoptosis and are taken up by macrophages. Neutrophils show pro-inflammatory activity and may contribute to tissue damage. In pneumococcal meningitis, neuronal damage despite adequate chemotherapy is a frequent clinical finding. This damage may be due to excessive neutrophil activity. We here show that transgenic expression of Bcl-2 in haematopoietic cells… CONTINUE READING

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