Apoptosis Induction by 1 , 25-Dihydroxyvitamin D 3 in Prostate Cancer 1

  title={Apoptosis Induction by 1 , 25-Dihydroxyvitamin D 3 in Prostate Cancer 1},
  author={Meral Guzey and Shinichi Kitada and John C. Reed},
Calcitriol [1 ,25-dihydroxyvitamin D3] is the natural ligand of the vitamin D receptor (VDR). Using cultured prostate cancer (PC) cell lines, LN-CaP and ALVA-31, we studied the effects of 1 ,25(OH)2-Vitamin D3 (VD3) on expression of several apoptosis-regulating proteins including: (a) Bcl-2 family proteins (Bcl-2, Bcl-XL, Mcl-1, Bax, and Bak); (b) the heat shock protein 70-binding protein BAG1L; and (c) IAP family proteins (XIAP, cIAP1, and cIAP2). VD3 induced decreases in levels of… CONTINUE READING


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