Defects in the apoptotic machinery of cancer cells: role in drug resistance.
- BiologySeminars in cancer biology
Tumor Resistance to Apoptosis
- Biology, Medicine
An understanding of the molecular mechanisms involved in the regulation of apoptosis and how tumor cells evade apoptotic death may provide insight into the processes of carcinogenesis and the progression of various malignancies, making it possible to use more rational approaches to antitumor therapy.
Impact of proapoptotic proteins Bax and Bak in tumor progression and response to treatment
- Biology, MedicineExpert review of anticancer therapy
The current understanding of mechanisms of apoptosis in normal and tumor cells as well as possible or existing strategies designed to induce specific and efficient cell death in cancers are summarized.
Modulation of apoptosis signaling for cancer therapy
- BiologyArchivum Immunologiae et Therapiae Experimentalis
Insight into the mechanisms regulating drug-induced apoptosis provide rational targets for novel therapeutic interventions and provide a paradigm to link cancer genetics and response to cancer therapy.
Apoptosis in Cancer Biology and Cancer Therapeutics
- Biology, Medicine
A better understanding of the molecular events that regulate apoptosis in cancers and upon cancer therapy provides the basis for a more rational approach to developing molecular targeted therapies in the fight against cancer.
Teaching cancer cells to die
- BiologyJournal of cellular biochemistry
Tumor cells have evolved numerous mechanisms to thwart apoptosis, and these apoptotic defects have fallen into the crosshairs of cancer drug developers.
Apoptosis in cancer--implications for therapy.
- BiologySeminars in oncology
The role of apoptosis signaling in tumorigenesis and drug resistance of tumor cells and therapeutic approaches interfering with apoptosis pathways are addressed.
Malate dehydrogenase 2 confers docetaxel resistance via regulations of JNK signaling and oxidative metabolism
- BiologyThe Prostate
Novel mechanistic understandings in cancer cell chemotherapeutic sensitivity and resistance can optimize treatment and improve patient outcome in prostate cancer therapeutics.
Chemotherapy response and resistance.
- Biology, MedicineCurrent opinion in genetics & development
Apoptosis and colorectal cancer: implications for therapy.
- BiologyTrends in molecular medicine
SHOWING 1-10 OF 234 REFERENCES
Proliferation, cell cycle and apoptosis in cancer
Deregulated cell proliferation provides a minimal 'platform' necessary to support further neoplastic progression and should be targeted withroit targeting to have potent and specific therapeutic consequences.
Apoptosis in cancer.
- Biology, MedicineCarcinogenesis
An intense research effort is uncovering the underlying mechanisms of apoptosis such that, in the next decade, one envisions that this information will produce new strategies to exploit apoptosis for therapeutic benefit.
Role of BAX in the apoptotic response to anticancer agents.
- Biology, MedicineScience
An unambiguous role for BAX in apoptotic processes in human epithelial cancers is established and may have implications for cancer chemoprevention strategies.
A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy.
- Biology, MedicineScience
This study has shown that a small molecule isolated for its ability to reversibly block p53-dependent transcriptional activation and apoptosis protected mice from the lethal genotoxic stress associated with anticancer treatment without promoting the formation of tumors.
Apoptosis, p53, and tumor cell sensitivity to anticancer agents.
- BiologyCancer research
Because wild-type p53 predisposes cells to a more rapid rate of cell death after DNA damage, that short-term assays have led to the conclusion that mutations in p53 confer resistance to genotoxic agents, this tenet may need to be reexamined for human tumors of nonhematological origin.
Genetic analysis of chemoresistance in primary murine lymphomas
- Biology, MedicineNature Medicine
It is demonstrated that the Bcl-2 oncoprotein produces multi-drug resistance when assessed inPrimary lymphomas in vivo, and this effect was dramatically reduced when the primary lymphomas were subjected to long-term culture, and completely missed in the standard clonogenic survival assay.
Inactivation of the apoptosis effector Apaf-1 in malignant melanoma
It is concluded that Apaf-1 is inactivated in metastatic melanomas, which leads to defects in the execution of apoptotic cell death, which may contribute to the low frequency of p53 mutations observed in this highly chemoresistant tumour type.
Regulation and function of the p53 tumor suppressor protein.
- BiologyCurrent opinion in cell biology
Rb function in cell-cycle regulation and apoptosis
- Biology, MedicineNature Cell Biology
The roles of Rb in regulating the cell cycle and apoptosis are reviewed and recent results linking these Rb functions to chromatin-remodelling enzymes are discussed.