Apoptosis A Link between Cancer Genetics and Chemotherapy

@article{Johnstone2002ApoptosisAL,
  title={Apoptosis A Link between Cancer Genetics and Chemotherapy},
  author={Ricky W. Johnstone and Astrid A. Ruefli and Scott W Lowe},
  journal={Cell},
  year={2002},
  volume={108},
  pages={153-164}
}
Defects in apoptosis underpin both tumorigenesis and drug resistance, and because of these defects chemotherapy often fails. Understanding the molecular events that contribute to drug-induced apoptosis, and how tumors evade apoptotic death, provides a paradigm to explain the relationship between cancer genetics and treatment sensitivity and should enable a more rational approach to anticancer drug design and therapy. 
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