Apoptosis: mode of cell death induced in T cell leukemia lines by dexamethasone and other agents.

@article{Bansal1991ApoptosisMO,
  title={Apoptosis: mode of cell death induced in T cell leukemia lines by dexamethasone and other agents.},
  author={Navin Bansal and Alain Houle and George Melnykovych},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={1991},
  volume={5 2},
  pages={211-6}
}
Glucocorticoids can mediate the destruction of thymocytes and T cell-derived leukemia cells through a mechanism known as apoptosis. The characteristic feature of apoptosis is fragmentation of DNA at internucleosomal linkers through the activity of a specific endonuclease. In this study, an attempt was made to compare dexamethasone-induced apoptosis in two T cell-derived human leukemia lines (CEM-C1 and CEM-C7) to the cell killing brought about by selected cytotoxic agents. In the CEM-C7 cell… CONTINUE READING
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