Apoptosis: mechanisms and relevance in cancer

@article{Vermeulen2005ApoptosisMA,
  title={Apoptosis: mechanisms and relevance in cancer},
  author={Katrien Vermeulen and Dirk R. Van Bockstaele and Zwi N Berneman},
  journal={Annals of Hematology},
  year={2005},
  volume={84},
  pages={627-639}
}
Apoptosis or programmed cell death is a process with typical morphological characteristics including plasma membrane blebbing, cell shrinkage, chromatin condensation and fragmentation. A family of cystein-dependent aspartate-directed proteases, called caspases, is responsible for the proteolytic cleavage of cellular proteins leading to the characteristic apoptotic features, e.g. cleavage of caspase-activated DNase resulting in internucleosomal DNA fragmentation. Currently, two pathways for… 

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