Apoptosis: its origin, history, maintenance and the medical implications for cancer and aging

@article{Kaczanowski2016ApoptosisIO,
  title={Apoptosis: its origin, history, maintenance and the medical implications for cancer and aging},
  author={Szymon Kaczanowski},
  journal={Physical Biology},
  year={2016},
  volume={13}
}
Programmed cell death is a basic cellular mechanism. Apoptotic-like programmed cell death (called apoptosis in animals) occurs in both unicellular and multicellular eukaryotes, and some apoptotic mechanisms are observed in bacteria. Endosymbiosis between mitochondria and eukaryotic cells took place early in the eukaryotic evolution, and some of the apoptotic-like mechanisms of mitochondria that were retained after this event now serve as parts of the eukaryotic apoptotic machinery. Apoptotic… 

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