Apoptosis: final common pathway of photoreceptor death in rd, rds, and rhodopsin mutant mice.

@article{Chang1993ApoptosisFC,
  title={Apoptosis: final common pathway of photoreceptor death in rd, rds, and rhodopsin mutant mice.},
  author={G Q Chang and Yuhan Hao and Fulton Wong},
  journal={Neuron},
  year={1993},
  volume={11 4},
  pages={595-605}
}
Mutations in the retinal degeneration, retinal degeneration slow(/peripherin) and rhodopsin genes cause photoreceptor degeneration in humans and mice. Although the phenotypes arising from these mutations are different, suggesting different mechanisms of pathogenesis, we present evidence that apoptosis may be the final common pathway of the disease process linking genotype to phenotype. We observed internucleosomal cleavage of retinal DNA by gel electrophoresis and fragmented DNA at the single… CONTINUE READING
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